Histone deacetylase 5 modulates the effects of social adversity in early life on cocaine-induced behavior

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• 作者：Alessandro Valzania^a ; Clarissa Catale^b ; Maria Teresa Viscomi^a ; Stefano Puglisi-Allegra^a ; ^c ; Valeria Carola^a ; ^{valeria.carola@uniroma1.it}
• 关键词：Cocaine ; c-Fos ; Conditioned place preference ; Histone deacetylase 5 ; Early life stress
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：171
• 期：Complete
• 页码：7-12
• 全文大小：513 K
• 卷排序：171

文摘

Heterozygous null mutation in HDAC5 moderated the effects of exposure to stress in early life on cocaine-mediated behavior. Heterozygous null mutation in HDAC5 moderates the effect of exposure to isolation but not to social threat in early age. Dorsal striatum mediates the interaction between heterozygous null mutation in HDAC5 and early isolation on cocaine-seeking.