Oxytocin pathways in the intergenerational transmission of maternal early life stress

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• 作者：Philipp Toepfer^a ; Christine Heim^a ; ^b ; Sonja Entringer^a ; ^c ; Elisabeth Binder^d ; ^e ; Pathik Wadhwa^c ; Claudia Buss^a ; ^c ; ^{claudia.buss@charite.de}
• 关键词：5HTTLPR ; Serotonin Transporter Length Polymorphic Region ; BPD ; Borderline Personality Disorder ; CNS ; Central Nervous System ; CpG ; Cytosine-Guanine DNA Sequence ; CRH ; Corticotropin Releasing Hormone ; CSF ; Cerebrospinal Fluid ; DA ; Dopamine ; DAT1 ; Dopamine Transporter Gene 1 ; DNA ; Deoxyribonucleic Acid ; DRD2 ; DRD4 ; Dopamine Receptor 2 and Dopamine Receptor 4 Genes ; E ; Estrogens ; ELS ; Early Life Stress ; GABA ; Gamma Amino Butric Acid ; HPA ; Hypothalamic Pituitary Adrenal Axis ; i.c.v. ; Intracerebrovent
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：293-308
• 全文大小：1895 K
• 卷排序：73

文摘

Oxytocin plays a role in the intergenerational transmission of early adversity. Putative pre- and postnatal OT pathways of transmission are proposed. Oxytocin receptor gene (OXTR) variants affect susceptibility to the environment. The role of OXTR DNA methylation is discussed as a mechanism of transmission. Critical assessment of methodological challenges in human OT research is provided.