Aerobic α-hydroxylation of β-keto esters and amides by co-catalysis of SmI3 and I2 under mild base-free conditions
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- 作者：Shun-Ming Yua ; Kai Cuia ; Fei Lvb ; Zhen-Yu Yanga ; ; Zhu-Jun Yaoa ; b ; yaoz@sioc.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aerobic oxidation ; 1 ; 3-Dicarbonyl compound ; Samarium(III) iodide ; Free radical ; Catalysis
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：22 June 2016
- 年：2016
- 卷：57
- 期：25
- 页码：2818-2821
- 全文大小：898 K
文摘
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Clean base-free α-hydroxylation of β-keto esters and amides with air.
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The first report of new binary catalytic system of SmI3 and I2.
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Wide scope of substrates, excellent yields, and mild conditions.
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Both oxygen atoms of dioxygen are utilized and incorporated into the product through a unique free-radical process.