Cardioprotective pleiotropic effects of statins are yet undefined Vitamin D displays antinflammatory and antithrombotic properties potentially mediating the anti-atherogenic benefits of statins We describe how the addition of a high-intensity statin provided a vitamin D raise in 246 patients with coronary artery disease Patients displaying the largest increase in vitamin D with statins showed a higher platelet inhibition on dual antiplatelet therapy.