Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging

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• 作者：Marie C. Lechler¹ ; ² ; Emily D. Crawford¹ ; ⁵ ; Nicole Groh¹ ; ² ; Katja Widmaier¹ ; Raimund Jung¹ ; Janine Kirstein³ ; Jonathan C. Trinidad⁴ ; ⁶ ; Alma L. Burlingame⁴ ; Della C. David¹ ; ⁷ ; ^{della.david@dzne.de}
• 关键词：neurodegenerative diseases ; Caenorhabditis elegans ; protein aggregation ; aging ; RNA-binding proteins ; stress granules ; HSF-1 ; DAF-2 ; longevity
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：454-467
• 全文大小：2865 K
• 卷排序：18

文摘

RNA-binding proteins (RBPs) with “prion-like” domains form solid aggregates with age Reduced daf-2 signaling preferentially prevents insolubility of RNA granule proteins Co-aggregation with other misfolded proteins promotes stress granule RBP aggregation Aggregation of key stress-granule-related RBPs is associated with impaired health