Dietary polychlorinated biphenyls, long-chain n-3 polyunsaturated fatty acids and incidence of malignant melanoma

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• 作者：Carolina Donat-Vargas^a ; Marika Berglund^a ; Anders Glynn^b ; Alicja Wolk^a ; Agneta &Aring ; kesson^a ; ^{Agneta.Akesson@ki.se}
• 关键词：Polychlorinated biphenyls (PCBs) ; Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) ; Cutaneous malignant melanoma ; Nutritional epidemiology ; Cancer prevention
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：137-143
• 全文大小：418 K
• 卷排序：72

文摘

Melanoma incidence continues to increase despite public education measures to limit sun exposure. This is the first prospective study evaluating dietary PCB exposure and melanoma. PCB exposure—mainly from fatty fish—was associated with a four-fold increased risk of melanoma. Eicosapentaenoic acid and docosahexaenoic acid intake was associated with 80% lower risk of melanoma. Adequately balancing the risk and benefits of fish consumption is a key public health issue.