5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma
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- 作者：Jeffrey P. Chenga ; b ; Jacob B. Learya ; b ; 1 ; Aerin Sembhia ; Clarice M. Edwardsa ; b ; Corina O. Bondia ; b ; e ; Anthony E. Klinea ; b ; c ; d ; e ; f ; klineae@upmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT1A receptor agonists ; Behavioral outcome ; Controlled cortical impact ; Functional recovery ; Hippocampus ; Learning and memory ; Morris water maze ; Serotonin1A ; Traumatic brain injury
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：1640
- 期：part_PA
- 页码：5-14
- 全文大小：493 K
文摘
- 55">
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5">5-HT1A receptor agonists facilitate cognitive recovery after experimental TBI.
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50">5-HT1A receptor agonists confer neuroprotection after experimental TBI.
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55">The benefits of 5-HT1A receptor agonists are seen when administered acutely and chronically after TBI.
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Some benefits of 5-HT1A receptor agonists can be augmented when combined with a preclinical model of neurorehabilitation.
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5">The 5-HT1A receptor agonist buspirone is used in other CNS disorders and thus translation to the clinic may be expedited.