Ambient UV-B exposure reduces the binding of ofloxacin with bacterial DNA gyrase and induces DNA damage mediated apoptosis
详细信息 查看全文
- 作者：Jyoti Singha ; e ; 1 ; Ashish Dwivedia ; b ; 1 ; Syed Faiz Mujtabaa ; Krishna P. Singhd ; Manish Kumar Palc ; Deepti Chopraa ; Shruti Goyala ; e ; Ajeet K. Srivastava ; Divya Dubeya ; Shailendra K. Guptad ; f ; Chandana Haldarb ; Ratan Singh Raya ; e ; rsray@iitr.res.in" class="auth_mail" title="E-mail the corresponding author ; ratanray.2001@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：OFLX ; UV-B ; DNA gyrase ; DNA damage ; Apoptosis
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：111-126
- 全文大小：5770 K
文摘
- •
OFLX generates two photoproducts after irradiation at ambient intensity of UV-B.
- •
Binding affinity of photosensitized OFLX with DNA gyrase attenuated.
- •
Photosensitized OFLX induced formation of micronuclei and CPDs.
- •
DNA damage and G1 phase cell cycle arrest and apoptosis.
- •
Upregulation of Bax, Cyt-c and Caspase-3 and downregulation of Bcl-2 proteins.