Functional roles and substrate specificities of twelve cytochromes P450 belonging to CYP52 family in n-alkane assimilating yeast Yarrowia lipolytica
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- 作者：Ryo Iwamaa ; Satoshi Kobayashia ; Chiaki Ishimarua ; Akinori Ohtab ; Hiroyuki Horiuchia ; Ryouichi Fukudaa ; afukuda@mail.ecc.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP or P450 ; cytochrome P450 ; DCA ; dicarboxylic acid ; ER ; endoplasmic reticulum ; GC&ndash ; MS ; gas chromatography&ndash ; mass spectrometry ; ORF ; open reading frame ; RACE ; rapid amplification of cDNA ends ; TMD ; transmembrane domain
- 刊名：Fungal Genetics and Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：43-54
- 全文大小：2849 K
文摘
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12 CYP52-family P450s encoded by ALK genes of Yarrowia lipolytica were characterized.
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Subsets of the Alk proteins oxidize n-alkane(s) and/or ω-terminus of dodecanoic acid.
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The ALK genes have been multiplicated and functionally diversified in Y. lipolytica.