Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)
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- 作者：Aya Shiraishia ; 1 ; Satsuki Mochizukia ; 1 ; Akira Miyakoshib ; Kanehisa Kojohb ; Yasunori Okadaa ; okada@z6.keio.jp" class="auth_mail" title="E-mail the corresponding author ; ya-okada@juntendo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADAMTS4 ; ADAMTS5 ; Aggrecanase ; Human antibody ; Cartilage ; Osteoarthritis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：469
- 期：1
- 页码：62-69
- 全文大小：1282 K
文摘
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Our antibody 237-53 is a human antibody obtained from phage display antibody library.
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The antibody specifically immunoreacts with human ADAMTS4 and ADAMTS5.
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ADAMTS4 and ADAMTS5 aggrecanase activity is efficiently inhibited by the antibody.
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Aggrecanase activity from osteoarthritic chondrocytes is inhibited by the antibody.
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The antibody is an exocite inhibitor specific to human aggrecanases.