An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers

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• 作者：Abdullah S. Madhun ; Per Espen Akselsen ; Haakon Sjursen ; Gabriel Pedersen ; Signe Svindl ; Jane Kristin Nø ; stbakken ; Mona Nilsen ; Kristin Mohn ; Å ; sne Jul-Larsen ; Ingrid Smith ; Diane Major ; John
• 关键词：Pandemic influenza H1N1 ; Vaccine ; Healthcare worker
• 刊名：Vaccine
• 出版年：2010
• 出版时间：16 December 2010
• 年：2010
• 卷：29
• 期：2
• 页码：266-273
• 全文大小：528 K

文摘

Mass vaccination was the most effective prophylaxis for protecting the population during the influenza H1N1 pandemic. We have evaluated the tolerability, immunogenicity and kinetics of the antibody response to a monovalent oil-in-water (AS03) adjuvanted human pandemic split influenza A/California/7/2009 H1N1 (3.75 μg haemagglutinin) vaccine in health care workers. Vaccination elicited a rapid and early protective level of haemagglutination inhibition antibody from 6 to 7 days post vaccination, and by 14 to 21 days post vaccination, up to 98 % of vaccinees had protective antibody titres which persisted for at least 3 months in 84–92 % of subjects. A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic.