Regio- and stereoselective modification of cytosine with cyanopropargylic alcohols

详细信息    查看全文

• 作者：Anastasiya G. Mal&rsquo ; kina ; Valentina V. Nosyreva ; Olesya A. Shemyakina ; Alexander I. Albanov ; Boris A. Trofimov ; ^{boris_trofimov@irioch.irk.ru}
• 刊名：Mendeleev Communications
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：27
• 期：1
• 页码：14-15
• 全文大小：202 K
• 卷排序：27

文摘

Cyanopropargylic alcohols (4-hydroxyalk-2-ynenitriles) add cytosine at the triple bond under mild conditions (3–5 mol% K2CO3, DMF, 20–25 °C, 2–3 h) to afford regio- and stereoselectively the Michael adducts, (Z)-3-[4-amino-2-oxo-1(2H)-pyrimidinyl]-4-hydroxy-4-alkylalk-2-enenitriles, in80–88% yield.