Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice

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• 作者：Francielle Graus-Nunes ; Thatiany de Souza Marinho ; Sandra Barbosa-da-Silva ; Marcia Barbosa Aguila ; Carlos Alberto Mandarim-de-Lacerda ; Vanessa Souza-Mello ; ¹ ; ^{souzamello.uerj@gmail.com}
• 关键词：Pancreatic islet ; Telmisartan ; Losartan ; Glucose homeostasis ; High-fat diet ; Apoptosis
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：54-64
• 全文大小：2772 K
• 卷排序：439

文摘

Obesity threatens pancreatic islet function and ARBs prevent type 2 diabetes onset. We compared two ARBs effects on pancreatic islet remodelling and function. Both ARBs preserved islet structure by greater blood flow and lower apoptosis. Losartan and Telmisartan rescued islet glucose sensing, with structural enhancement. GLP-1 and PDX1 mediate additional telmisartan effects on glucose homeostasis.