Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects
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- 作者：Aleida Nú ; ñ ; ez Ruiz ; M.Sc.a ; Juan Diego Corté ; s-Garcia ; M.Sc.a ; Nancy Cortez-Espinosa ; Ph.D.a ; Paola Indira Herrera-Rojas ; Q.FB.a ; Ví ; ctor Manuel Ruí ; z-Rodrí ; guez ; Q.FB.a ; Mariana Salgado-Bustamante ; Ph.D.b ; Mariana Haydee Garcí ; a-Herná ; ndez ; Ph.D.c ; Elizabeth Reynaga-Herná ; ndez ; Ph.D.a ; Veronica del Carmen Martí ; nez-Jimenez ; Ph.D.a ; Diana Patricia Portales-Pé ; rez ; Ph.D.a ; dportale@uaslp.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Infiltrated lymphocytes ; Sirt1 ; Treg cells ; Foxp3 ; Overweight ; PPAR-γ
- 刊名：Nutrition
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：32
- 期：9
- 页码：943-954
- 全文大小：1357 K
文摘
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Low levels of CD4+CD39+Foxp3+ cells are associated with increased body mass index.
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We found diminished levels of regulatory T cell subsets in adipose tissue from overweight subjects.
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Increased levels of Sirt1 protein allows adipose tissue mononuclear cells respond to adenoside receptors and sirtuin pathways.
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Low levels of Sirt1 and peroxisome proliferator-activated receptor gamma mRNA in adipose tissue mononuclear cells from overweight subjects was detected.
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High inhibition percentage of proliferation and Foxp3 protein levels could be related.