‘Mitotherapy‿for Heart Failure

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• 作者：Fabian Sanchis-Gomar¹ ; ^{fabian.sanchis@uv.es" class="auth_mail" title="E-mail the corresponding author} ; Giuseppe Lippi² ; Alejandro Lucia¹ ; ³
• 关键词：heart ; pathway ; aging
• 刊名：Trends in Molecular Medicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：22
• 期：4
• 页码：267-269
• 全文大小：593 K

文摘

Abnormalities in mitochondrial dynamics along with those for the molecular mediators involved are presently being viewed with increased interest in the field of cardiovascular disease. Recent research highlights OPA1, a dynamin-like GTPase mediating mitochondrial fusion, as well as the ‘mitoproteases’ OMA1 and YME1L, as potential therapeutic targets against heart failure.