Paraphilic Sexual Offenders Do Not Differ From Control Subjects With Respect to Dopamine- and Serotonin-Related Genetic Polymorphisms

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• 作者：Andrzej Jakubczyk ; MD ; PhD¹ ; Aleksandra Krasowska ; MD ; PhD¹ ; ^{aleksandra.krasowska@gmail.com} ; Marcin Bugaj ; MD¹ ; Maciej Kopera ; MD ; PhD¹ ; Anna Klimkiewicz ; MD ; PhD¹ ; Agata Łoczewska ; MD¹ ; Aneta Michalska ; MD¹ ; Aleksandra Majewska ; MD¹ ; Natalia Szejko ; MD² ; ³ ; Anna Podgó ; rska⁴ ; Małgorzata Sołowiej ; MD¹ ; Leszek Markuszewski ; MD ; PhD⁵ ; Sławomir Jakima ; MD⁶ ; Rafał Płoski ; MD ; PhD⁷ ; Kirk Brower ; MD⁸ ; Marcin Wojnar ; MD ; PhD¹ ; ⁸
• 关键词：Sexual Offense ; Pedophilia ; Genetic Polymorphism ; Serotonin ; Dopamine
• 刊名：The Journal of Sexual Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：14
• 期：1
• 页码：125-133
• 全文大小：265 K
• 卷排序：14

文摘

Rape and pedophilic child molestation are the most commonly convicted sexual offenses in Poland. Recent studies have suggested a possible genetic contribution toward pathologic sexual interests and behaviors.AimTo analyze and compare functional polymorphisms of genes associated with the activity of the serotonin and dopamine systems in a group of paraphilic sexual offenders and control subjects.MethodsThe study sample (n = 97) consisted of two groups: paraphilic sexual offenders (65 pedophilic child molesters and 32 rapists) and controls (n = 76). Genetic polymorphisms previously associated with behavioral control, addictive behaviors, and sexual functions were chosen for analyses. Specifically, functional polymorphisms in dopamine receptors genes (DRD1, DRD2, DRD4), catechol-O-methyltransferase gene (COMT), dopamine transporter gene (DAT), serotonin transporter gene (SLC6A4), serotonin type 2A receptor gene (5HTR2A), tryptophan hydroxylase 2 gene (TPH2), monoamine oxidase A gene (MAOA), and brain-derived neurotrophic factor gene (BDNF) were analyzed.Main Outcome MeasuresAn association between a history of sexual offense and the distribution of genotypes and alleles in the analyzed polymorphisms.ResultsOur results found no association between a history of sexual offense and the distribution of genotypes or alleles in the analyzed polymorphisms.ConclusionAlthough these results are limited by the small sample and are exploratory, they highlight a novel approach to sample selection in a population that is difficult to access and study. Future research should include larger samples and other relevant polymorphisms to advance this field of study.