Overview on gastroretentive drug delivery systems for improving drug bioavailability

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• 作者：Carla M. Lopes^a ; ^{cmlopes@ufp.edu.pt" class="auth_mail" title="E-mail the corresponding author} ; Catarina Bettencourt^a ; Alessandra Rossi^b ; Francesca Buttini^b ; ^c ; Pedro Barata^a ; ^{pbarata@ufp.edou.pt" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Narrow absorption window ; Controlled drug release ; Gastroretentive system ; Gastric retention time ; Multiple unit dosage form
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：20 August 2016
• 年：2016
• 卷：510
• 期：1
• 页码：144-158
• 全文大小：1028 K

文摘

In recent decades, many efforts have been made in order to improve drug bioavailability after oral administration. Gastroretentive drug delivery systems are a good example; they emerged to enhance the bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract and/or to promote local activity in the stomach and duodenum. Several strategies are used to increase the gastric residence time, namely bioadhesive or mucoadhesive systems, expandable systems, high-density systems, floating systems, superporous hydrogels and magnetic systems. The present review highlights some of the drugs that can benefit from gastroretentive strategies, such as the factors that influence gastric retention time and the mechanism of action of gastroretentive systems, as well as their classification into single and multiple unit systems.