Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls
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- 作者：Shu Xiaa ; b ; xiashutj@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Chiang-Ching Huangc ; huangcc@uwm.edu" class="auth_mail" title="E-mail the corresponding author ; Min Leb ; mle@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Rachel Dittmarb ; rdittmar@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Meijun Dub ; mdu@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Tiezheng Yuanb ; tyuan@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Yongchen Guob ; gyongchen@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Yuan Wangb ; yuwang@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Xuexia Wangc ; xuexia@uwm.edu" class="auth_mail" title="E-mail the corresponding author ; Susan Tsaid ; stsai@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Saul Susterb ; ssuster@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Alexander C. Mackinnonb ; amackinnon@mcw.edu" class="auth_mail" title="E-mail the corresponding author ; Liang Wangb ; liwang@mcw.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Non-small cell lung cancer ; Plasma ; cfDNA ; Next generation sequencing ; Copy number variations ; Digital PCR ; Allele-specific PCR
- 刊名：Lung Cancer
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：90
- 期：1
- 页码：78-84
- 全文大小：1249 K
文摘
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Developed a novel plasma genomic abnormality (PGA) score for CNV analysis.
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Demonstrated potential use of PGA scores in early detection of lung cancer.
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Showed detectable gene mutations in early stage lung cancer.