TNFα and anti-Fas antibodies regulate Ly-6E.1 expression by tumor cells: A possible link between angiogenesis and Ly-6E.1
详细信息 查看全文
- 作者：Sagi-Assif ; Orit ; Traister ; Alexandra ; Katz ; Ben-Zion ; Anavi ; Romema ; Eskenasy ; Marsel ; Witz ; Isaac P.
- 关键词：Anti-fas antibodies ; Ly-6E.1 expression ; TNFα ; Tumor cells
- 刊名：Immunology Letters
- 出版年：1996
- 出版时间：December 2, 1996
- 年：1996
- 卷：54
- 期：2-3
- 页码：207-213
- 全文大小：554 K
文摘
Angiogenic and poorly angiogenic tumor variants were obtained by an intraperitoneal inoculation of cells from clones of polyoma-virus transformed BALB/c 3T3 cells into syngeneic mice. The angiogenic tumor cells expressed a higher tumorigenicity phenotype and a higher capacity to produce artificial pulmonary metastases than cells from the poorly angiogenic tumors. The former cells expressed also significantly higher levels of the lymphocyte activation protein Ly-6E.1 than the former cells. The two types of cells did not differ in expression levels of CD44 and of a polyoma-virus specific membrane antigen. These results raise the possibility that the angiogenic phenotype is coregulated with Ly-6. The effect on Ly-6 expression of signal transduction through TNF receptors, functioning as pivotal regulators of angiogenesis was therefore studied. It was found that TNFα and more so antibodies against Fas down-regulate expression levels of Ly-6. This down-regulation seemed to be selective as expression levels of CD44 were not affected by this treatment.