Comparative analyses of the proteins from Mycobacterium tuberculosis and human genomes: Identification of potential tuberculosis drug targets
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- 作者：Settu Sridhar sridhar@ccmb.res.in" class="auth_mail" title="E-mail the corresponding author ; Pallabini Dash pallabini@ccmb.res.in" class="auth_mail" title="E-mail the corresponding author ; Kunchur Guruprasad ; guru@ccmb.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：TB ; Tuberculosis ; MDRTB ; Multi-drug-resistant tuberculosis ; XDRTB ; Extensively-drug resistant tuberculosis ; IPW ; Interactome pathway ; NCBI ; National Center for Biotechnology Information ; PSI-BLAST ; Position Specific Iterative &mdash ; Basic Local Alignment Search Tool ; MCODE ; Molecular Complex Detection ; PDB ; Protein Data Bank ; PMP ; Protein Model Portal ; ATP ; Adenosine triphosphate ; ADP ; Adenosine diphosphate ; DNA ; DEOXYRIBONUCLEIC acid ; MCE ; mammalian cell entry
- 刊名：Gene
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：579
- 期：1
- 页码：69-74
- 全文大小：844 K
文摘
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Protein sequences from 23 M.tb genome strains and Homo sapiens compared
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1,478 ‘conserved’ M.tb proteins absent in human identified
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94 interacting M.tb proteins prioritized as potential new TB targets for validation.
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10 ‘druggable’ TB targets with known drugs identified
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Prediction of drug targets using bioinformatics depends upon methods and datasets used.