An antibiotic target ranking and prioritization pipeline combining sequence, structure and network-based approaches exemplified for Serratia marcescens
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- 作者：Shishir K. Guptaa ; b ; shishir.gupta@uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author ; Roy Grossb ; roy@biozentrum.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author ; Thomas Dandekara ; c ; dandekar@biozentrum.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：DEG ; database of essential genes ; CV ; composition vector ; Crp ; cyclic AMP (cAMP) receptor protein ; GmhB ; D ; D-heptose 1 ; 7-bisphosphate phosphatase ; PPI ; protein-protein interaction ; DIP ; Database of Interacting Proteins ; BlastP ; basic local alignment sequence tool for proteins ; S. marcescens ; Serratia marcescens ; MCL ; Markov clustering ; E ; expected value
- 刊名：Gene
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：591
- 期：1
- 页码：268-278
- 全文大小：1485 K
文摘
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Drug targets are screened by sequence, structure and network-based criteria.
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Serratia marcescens, an opportunistic pathogen, serves as test case.
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We identify 45 potential anti-microbial drug targets in S. marcescens.
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KdsA involved in LPS, LpxC and FlgB are top-ranked targets identified.