Expression of stem cell markers in oral cavity and oropharynx squamous cell carcinoma

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• 作者：Flá ; via Paiva Prudente de Moraes ; MD^a ; ^b ; Silvia Vanessa Lourenç ; o ; PhD^c ; Renata Carolina Fraga Ianez ; PhD^a ; ^b ; Elen Alves de Sousa ; MSc^a ; ^b ; Marlon Messias da Conceiç ; ã ; o Silva ; BSc^a ; ^b ; Aline Santos Damascena ; BSc^a ; Luiz Paulo Kowalski ; MD ; PhD^d ; Fernando Augusto Soares ; MD ; PhD^b ; ^c ; Clá ; udia Malheiros Coutinho-Camillo ; PhD^a ; ^b ; ^{ccamilo@cipe.accamargo.org.br}
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：123
• 期：1
• 页码：113-122
• 全文大小：3369 K
• 卷排序：123

文摘

The aim of this study was to analyze the expression of CD24, CD44, CD133, ALDH1, CD29 (integrin-β1), and Ki-67 in squamous cell carcinoma of the oral cavity and oropharynx.Study DesignFifty-two tumors and 21 metastatic lymph nodes were evaluated by using immunohistochemistry.ResultsSeven of 52 cases (13.5%) showed positive cytoplasmic staining of aldehyde dehydrogenase 1; integrin-β1 was expressed in 45 of 50 cases (90%); 30 of 52 cases (57.7%) had positive membranous staining of CD44; CD24 was expressed in 44 of 50 cases (88%); and three of 52 cases (5.8%) stained positively for membranous CD133. Median proliferation rate, measured by Ki-67, was 37.1% for tumors. Five-year cancer-specific survival rates for the CD44-negative and CD44-positive groups were 74% and 38%, respectively, although this difference did not reach statistical significance (P = .052).ConclusionsOur study demonstrated the expression of putative stem cell markers in squamous cell carcinoma of the oral cavity and oropharynx, with participation of CD44-positive cells in association with poor survival outcome.