Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4

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• 作者：Nazli Alizadeh-Tabrizi^a ; Hassan Malekinejad^a ; ^b ; ^{hassanmalekinejad@yahoo.com} ; Soheil Varasteh^c ; Hadi Cheraghi^a
• 关键词：Alveolar macrophages ; Atorvastatin ; Cytotoxicity ; Paraquat ; Toll like receptor-4
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：8-13
• 全文大小：762 K
• 卷排序：49

文摘

Paraquat exert cytotoxicity on Alveolar macrophages via oxidative and nitrosative stress. Paraquat cytotoxicity on alveolar macrophages mediated via up-regulation of TLR-4 expression. Atorvastatin regulated the Paraquat-induced expression of TLR-4 in alveolar macrophages.