Identification of bone morphogenetic protein 9 (BMP9) as a novel profibrotic factor in vitro
详细信息 查看全文
- 作者：José ; M. Muñ ; oz-Fé ; lixa ; b ; Cristina Cuestaa ; b ; 1 ; Nuria Perretta-Tejedora ; b ; 1 ; Mariela Subileauc ; Francisco J. Ló ; pez-Herná ; ndeza ; b ; d ; José ; M. Ló ; pez-Novoaa ; b ; Carlos Martí ; nez-Salgadoa ; b ; d ; carlosms@usal.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMP9 ; ALK1 ; ALK5 ; Fibroblasts ; Fibrosis ; Extracellular matrix proteins
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1252-1261
- 全文大小：1372 K
文摘
- •
BMP9 increases collagen I, fibronectin and CTGF/CCN2 expression in fibroblasts.
- •
BMP9 promotes both Smad1/5/8 and Smad2/3 phosphorylation in fibroblasts.
- •
ALK1 is necessary for BMP9 to induce Smad1/5/8 and Smad2/3 phosphorylation.
- •
Overexpression of endoglin increases BMP9-induced Smad1/5/8 and Smad2/3 phosphorylation and its profibrotic properties.