Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development
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- 作者：Keiko Uchidaa ; b ; ; Maki Nakazawaa ; Chihiro Yamagishia ; Katsuhiko Mikoshibac ; Hiroyuki Yamagishia ;
- 关键词：Embryonic vessels ; Placental labyrinth ; Allantois ; Yolk sac ; Intracellular calcium signaling ; Angiogenesis
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：418
- 期：1
- 页码：89-97
- 全文大小：5091 K
文摘
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IP3R type 1 (IP3R1) and type 3 (IP3R3) were expressed in extra-embryonic tissues.
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IP3R1 and IP3R3 were expressed in vascular endothelium.
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IP3R1−/−IP3R3−/− mutant embryos were embryonic lethal.
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Poor elongation of extra-embryonic mesoderm into the labyrinth of IP3R1−/−IP3R3−/− mutants.
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The vessels in IP3R1−/−IP3R3−/− allantois and yolk sac were disorganized.