Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions

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• 作者：Camila P. Almeida-Suhett ; ^{camila.almeida.ctr@usuhs.edu} ; Alice Graham ; Yifan Chen ; Patricia Deuster
• 关键词：High-fat diet ; Hippocampus ; Amygdala ; Cognitive deficit ; Anxiety-like behavior ; Interleukin-1β
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：169
• 期：Complete
• 页码：130-140
• 全文大小：1142 K
• 卷排序：169

文摘

Mice fed a high-fat diet (HFD) develop cognitive deficit and anxiety-like behavior. Expression of IL-1β is increased in the hippocampus and amygdala of HFD mice. Cognitive deficit correlates with levels of IL-1β in the hippocampus and amygdala Levels of IL-1β in the amygdala correlates with anxiety-like behavior Excessive weight gain is not necessary metabolic and behavioral changes to occur.