Dichotomous effects of isomeric secondary amines containing an aromatic nitrile and nitro group on human aortic smooth muscle cells via inhibition of cystathionine-γ-lyase
Two isomeric families (O and P) of N-alkyl-N-aryl amines are reported. The O family of amines induce and inhibit HASMC proliferation at low and at high concentrations respectively. The P family of amines inhibit HASMC proliferation at all concentrations. Amines belonging to the O family inhibit cystathionine-γ-lyase to a lower extent than the P family. The O and P families of amines increase intracellular homocysteine levels to varying extents.