13-week dietary study and in vitro and in vivo genotoxicity studies of a structuring fat produced through a microalgal fermentation process

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• 作者：R.A. Matulka^a ; ^{rmatulka@burdockgroup.com} ; T. Chan^b ; R. Green^b ; J.R. Carney^b ; S. Franklin^b ; P. Licari^b
• 关键词：2-AA ; 2-aminoanthracene ; AAALAC ; Association for Assessment and Accreditation of Laboratory Animal Care International ; ANOVA ; Analysis of Variance ; AOAC ; Association of Analytical Communities ; AOCS ; American Oil Chemists&rsquo ; Society ; ASTM ; American Society for Testing and Materials ; bw ; Body weight ; GLP ; Good laboratory practice ; CPA ; Cyclophosphamide ; cps ; Centipoise ; DHA ; Docosahexaenoic acid ; g ; Gram ; EPA ; Eicosapentaenoic acid ; GRAS ; Generally recognized as safe ; GRN ; GRAS notification ; I
• 刊名：Toxicology Reports
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：123-134
• 全文大小：596 K
• 卷排序：3

文摘

The dietary safety of a unique microalgal structuring fat produced by a heterotrophic fermentation process was assessed. The algal fat was non-mutagenic in Salmonella typhimurium and Escherichia coli tester strains at up to 5000 μg/plate. The algal fat was non-clastogenic in mouse bone marrow after a single oral dose at 2000 mg/kg bw. Dietary NOAEL of the algal structuring fat for rats in a 13-week study was 100 000 ppm, the highest concentration tested. Based on consumption, the oral NOAEL for the algal structuring fat in rats was 5299 (male) and 6313.8 (female) mg/kg bw/day.