Convenient enantioselective synthesis of β-trifluoromethyl-β-aminoketones by organocatalytic asymmetric Mannich reaction of aryl trifluoromethyl ketimines with acetone
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- 作者：Volodymyr A. Sukach ; Nataliya M. Golovach ; Volodymyr V. Pirozhenko ; Eduard B. Rusanov ; Mykhaylo V. Vovk
- 关键词：Anxiety ; Clinical trial ; Depression ; Psychotherapy ; Randomization ; Work ability
- 刊名：Tetrahedron: Asymmetry
- 出版年：2008
- 出版时间：3 April 2008
- 年：2008
- 卷：19
- 期：6
- 页码：761-764
- 全文大小：225 K
文摘
The l-proline-catalyzed asymmetric Mannich reaction has been performed between aryl trifluoromethyl ketimines and acetone to provide, for the first time, chiral β-aryl-β-trifluoromethyl-β-aminoketones in high yields and with 74–92 % enantiomeric excesses.