Medicinal attributes of pyrazolo[1,5-a]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

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• 作者：Nasser S.M. Ismail^a ; ^b ; ^{saadnasser2003@yahoo.com} ; Ghada M.E. Ali^c ; Diaa A. Ibrahim^c ; Amira M. Elmetwali^c
• 关键词：Protein kinase ; Bioisostere ; Pyrazolo[1 ; 5-a]pyrimidine ; Anticancer
• 刊名：Future Journal of Pharmaceutical Sciences
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：2
• 期：2
• 页码：60-70
• 全文大小：1450 K
• 卷排序：2

文摘

Pyrazolo pyrimidines are fused heterocyclic ring systems which known as bioisosteres of adenine, that are necessary for every aspect of cell life. Pyrazolo[1,5-a]pyrimidines derivatives have been explored for their inhibitory activity towards a variety of protein kinase enzymes and their function as anticancer agents. This review to the best of our knowledge is the first assemblage on synthesis and medicinal aspects including structure activity relationships of pyrazolo[1,5-a]pyrimidines reported to date.