Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition
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- 作者：Chao Liua ; Ping Zhub ; Wangsheng Wangd ; Wenjiao Lic ; d ; Qun Shuc ; Zi-Jiang Chend ; Leslie Myatte ; Kang Sund ; sungangrenji@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amnion ; Prostaglandin E2 ; Cyclooxygenase-2 ; Lysyl oxidase ; Parturition
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：424
- 期：Complete
- 页码：118-127
- 全文大小：2183 K
文摘
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Reduction of PGE2 by COX-2 knock-down increases LOX level in amnion fibroblasts.
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PGE2 decreases LOX abundance via EP2/EP4 receptor-coupled cAMP/PKA pathway.
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PGE2 increases COX-2 abundance via EP2/EP4 receptor-coupled cAMP/PKA pathway.
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Increase of COX-2 and decrease of LOX are associated with labor in the amnion.
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A feed-forward inhibition of LOX by PGE2 exists in the amnion toward term.
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