Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats
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- 作者：Ezia Guatteoa ; b ; e.guatteo@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Romana Rizzoa ; c ; rizzo.francescaromana@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mauro Federicia ; m.federici@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author ; Alberto Cordellaa ; c ; alberto_cordella@live.it" class="auth_mail" title="E-mail the corresponding author ; Ada Ledonnea ; adaledonne@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Laura Latinia ; l.latini@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author ; Annalisa Nobilia ; f ; nobili.annalisa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Maria Teresa Viscomia ; mt.viscomi@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author ; Filippo Biamonted ; filippo.biamonte@rm.unicatt.it" class="auth_mail" title="E-mail the corresponding author ; Kerstin K. Landrocke ; KLandrock@cvm.tamu.edu" class="auth_mail" title="E-mail the corresponding author ; Alessandro Martinia ; c ; alex1martini@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Daniela Aversaa ; c ; daniela.biotech@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Chiara Schepisia ; chiara.schepisi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Marcello D'Amelioa ; f ; m.damelio@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author ; m.damelio@unicampus.it" class="auth_mail" title="E-mail the corresponding author ; Nicola Berrettaa ; n.berretta@hsantalucia.it" class="auth_mail" title="E-mail the corresponding author ; Nicola B. Mercuria ; c ; mercurin@med.uniroma2.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-syn ; α-synuclein ; m/m ; homozygous mutant rats ; ; +/+ ; ; control animals ; PD ; Parkinson's disease ; LBs ; Lewy bodies ; SNpc ; substantia nigra pars compacta ; VTA ; ventral tegmental area ; DA ; dopamine ; DAergic neurons ; dopaminergic neurons ; MSNs ; medium spiny neurons ; MEA ; multi-electrode array ; CPA ; constant potential amperometry ; DAT ; dopamine transporter ; HCN ; hyperpolarization-activated cyclic nucleotide-gated channels ; GIRK ; G-protein coupled inward rectifier potassium channels ; MPH ; m
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：21-33
- 全文大小：1629 K
文摘
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α-syn accumulates in the mesencephalon, striatum and frontal cortex of m/m rats.
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SNpc DAergic neurons from m/m rats show normal functional activity.
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The number of SNpc DAergic neurons from m/m rats is 9% reduced.
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Dopamine and glutamate release in the striatum from m/m rats is impaired.
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Loss of striatal DAT- and VGluT1-expressing terminals occurs in m/m rats.