Disassembly of amphiphilic small molecular prodrug with fluorescence switch induced by pH and folic acid receptors for targeted delivery and controlled release

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• 作者：Zhigang Xu^a ; ^b ; ^{zgxu@swu.edu.cn} ; Xiaoxiao Shi^a ; ^b ; Meili Hou^a ; ^b ; Peng Xue^a ; ^b ; Yong-E Gao^a ; ^b ; Shiying Liu^c ; Yuejun Kang^a ; ^b ; ^{yjkang@swu.edu.cn} ; ^{yuejun.kang@outlook.com}
• 关键词：Small molecular prodrug ; Drug delivery ; Controlled release ; Cancer therapy ; Diagnosis
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：50-58
• 全文大小：2213 K
• 卷排序：150

文摘

A folate-DOX amphiphilic small molecular prodrug is conjugated by hydrazone bond. The prodrug assembles into micellar nanoparticles at low critical concentration. These nanoparticles disassemble in acidic condition or with folate receptors. The hydrazone bond breaks releasing drug load in acidic endosomal environment.