Sensitive SERS detection of DNA methyltransferase by target triggering primer generation-based multiple signal amplification strategy
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- 作者：Ying Li ; Chuanfeng Yu ; Huixia Han ; Caisheng Zhao ; Xiaoru Zhang ; zhangxr7407@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Surface-enhanced Raman scattering ; Target triggering primer generation ; DNA methyltransferase ; Multiple signal amplification
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：81
- 期：Complete
- 页码：111-116
- 全文大小：1118 K
文摘
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A target triggering primer generation-based multiple signal amplification strategy is developed.
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The method is successfully used for SERS detection of DNA methyltransferase.
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A wide dynamic range and remarkably high sensitivity are obtained.
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This assay exhibits an excellent selectivity and is successfully applied in inhibitor screening.