Influence of surface passivation of 2-Methoxyestradiol loaded PLGA nanoparticles on cellular interactions, pharmacokinetics and tumour accumulation

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• 作者：Gopikrishna J. Pillai ; Bindhu Paul-Prasanth ; Shantikumar V. Nair ; ^{shantinair@aims.amrita.edu} ; Deepthy Menon ; ^{deepthymenon@aims.amrita.edu}
• 关键词：2-Methoxyestradiol ; PLGA nanoparticles ; Drug delivery ; Breast cancer ; Pharmacokinetics ; Tumour accumulation ; Protein binding
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：242-249
• 全文大小：1338 K
• 卷排序：150

文摘

Efficient nanoencapsulation of 2-ME2 in Casein/PEG stabilized PLGA Particles of similar size and surface charge developed by emulsification process PEGylation improved the pharmacokinetics of 2-ME2 over Casein stabilization Differential protein binding onto nanoparticles might be responsible for this effect