Enhanced alcohol-drinking behavior associated with active ghrelinergic and serotoninergic neurons in the lateral hypothalamus and amygdala

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• 作者：Kanji Yoshimoto^a ; ^f ; ^{k.yoshimoto.ud@it-hiroshima.ac.jp} ; Masataka Nagao^a ; Yoshihisa Watanabe^b ; Takashi Yamaguchi^c ; Shuichi Ueda^c ; Yoshihisa Kitamura^d ; Kaneyasu Nishimura^d ; Masatoshi Inden^d ; Yoshinori Marunaka^e ; Hiroyuki Hattori^f ; Kaori Murakami^f ; Megumi Tokaji^f ; Kozo Ochi^f
• 关键词：(GHS-R1A) ; growth hormone secretagogue receptor 1A ; (EtOH) ; ethanol ; (i.p.) ; intraperitoneally ; (STA) ; short-term alcohol vapor-exposed ; (LTA) ; long-term alcohol vapor-exposed ; (LH) ; lateral hypothalamus ; (DA) ; dopamine ; (5-HT) ; serotonin ; [VTA] ; ventral tegmental area ; [ACC] ; nucleus accumbens ; (CNS) ; central nervous system ; (ELISA) ; enzyme-linked immunosorbent assay ; (aCSF) ; artificial cerebrospinal fluid ; (SDS) ; sodium dodecyl sulfate ; (EDTA) ; disodium-ethylenediaminetetraacetic acid ; (PCR)
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：153
• 期：Complete
• 页码：1-11
• 全文大小：1236 K
• 卷排序：153

文摘

Alcohol decreased plasma ghrelin in one- and 3-month old short- term alcohol vapor-exposed (STA) mice. Alcohol-induced plasma ghrelin levels were increased in the long-term alcohol vapor-exposed (LTA) mice. Lateral hypothalamus (LH) alcohol-induced ghrelin releases were increased in both models. Characteristic increases of LH serotonin releases were shown in the LTA following alcohol administration. Positive ghrelin receptor cells and their proteins were increased in the LH and central amygdala of the only LTA.