Antidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice

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• 作者：Sachie Sasaki-Hamada^a ; ^c ; Ryuji Nakamura^a ; Yusuke Nakao^b ; Toshiki Akimoto^a ; Emi Sanai^a ; Mio Nagai^b ; Michiko Horiguchi^b ; ^d ; Chikamasa Yamashita^b ; ^d ; Professor Jun-Ichiro Oka^a ; ^c ; ^{okaji@rs.noda.tus.ac.jp}
• 关键词：ACTH ; adrenocorticotropic hormone ; BBB ; blood-brain barrier ; BLA ; basolateral amygdala ; CNS ; central nervous system ; CPPs ; cell penetrating peptides ; DMH ; dorsomedial hypothalamic nucleus ; DMSO ; dimethylsulfoxide ; DPP-IV ; dipeptidyl peptidase IV ; FAM ; carboxyfluorescein ; FITC ; fluorescein isothiocyanate ; FST ; forced-swim test ; Fos ; c-fos protein ; GLP-2 ; glucagon-like peptide-2 ; HPA ; hypothalamic-pituitary-adrenal ; i.c.v. ; intracerebroventricular ; IL ; infralimbic cortex ; i.n. ; intranasal ; OB ; olf
• 刊名：Peptides
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：64-70
• 全文大小：1196 K
• 卷排序：87

文摘

PAS-CPPs-GLP-2 (i.n.) exerted antidepressant-like effects in naïve mice. PAS-CPPs-GLP-2 (i.n.) also exerted antidepressant-like effects in ACTH-treated mice. PAS-CPPs-GLP-2 (i.v.) and CPPs-GLP-2 (i.n.) did not affect the FST immobility time. FITC-labeled PAS-CPPs-GLP-2 (i.n.) was distributed through the mouse brain. PAS-CPPs may enhance the i.n. delivery to the brain compared with CPPs only.