Amylin and Leptin: Co-Regulators of Energy Homeostasis and Neuronal Development

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• 作者：Barry E. Levin¹ ; ^{levin@njms.rutgers.edu} ; Thomas A. Lutz²
• 关键词：leptin ; amylin ; area postrema ; hypothalamus ; ventral tegmental area ; NPY/AgRP ; POMC
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：153-164
• 全文大小：2216 K
• 卷排序：28

文摘

While the regulation of energy homeostasis by amylin is already well-characterized, emerging data suggest that amylin is also crucial for the development of neural pathways in the hypothalamus and caudal hindbrain (area postrema, AP; nucleus tractus solitarius, NTS). Exciting new findings demonstrate crucial amylin–leptin interactions in altering the activity of specific hypothalamic and AP neurons, and a role for amylin as a novel class of ‘leptin sensitizers’ which enhance leptin signaling in both leptin-sensitive and -resistant individuals, in part by stimulating IL-6 production by hypothalamic microglia. This review summarizes these findings and provides a hypothetical framework for future studies to elucidate the mechanisms by which amylin and leptin act individually and as co-conspirators to alter energy homeostasis and neuronal development.