Butyrylcholinesterase knockout (BChE KO) mice showed enhanced learning ability in spatial and non-spatial memory tests.
10">In BChE KO mice, the amyloid β25–35 peptide-induced deficit in place learning was attenuated in males and blocked in females.
15">No change in oxidative stress or ACh levels was observed after Aβ25–35 in BChE KO mice.
Genetic invalidation of BChE in mice augmented learning capacities and lowered the vulnerability to Aβ toxicity.