Leptin/OB-R signaling is elevated in mice with Sjögren's syndrome and is implicated in disease pathogenesis

详细信息    查看全文

• 作者：Ting Xu ; Wen Xie ; Yingchun Ma ; Shiliang Zhou ; Lu Zhang ; Jinyun Chen ; Mingyuan Cai ; Rurong Sun ; Peirong Zhang ; Shaobo Yu ; Zheng Xu ; Wanlan Jiang ; Min Wu ; ^{wuumin_2016@163.com}
• 关键词：Sjö ; gren's syndrome (SjS) ; B lymphocyte ; Leptin ; Leptin receptor (OB-R)
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：835-842
• 全文大小：2252 K
• 卷排序：482

文摘

Leptin receptor was mostly expressed in the submandibular salivary gland tissues in the NOD/LtJ SjS model mice, while leptin was mostly expressed by the infiltrated B lymphocyte. Leptin receptro down-regulation in salivary glands attenuates the pathologic process of SjS in the NOD/LtJ mice. Leptin/OB-R signaling may be pathogenically involved in SjS and may serve as a new marker and a potential therapeutic target.