Autonomous Metabolic Oscillations Robustly Gate the Early and Late Cell Cycle

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• 作者：Alexandros Papagiannakis¹ ; Bastian Niebel¹ ; Ernst C. Wit² ; Matthias Heinemann¹ ; ³ ; ^{m.heinemann@rug.nl}
• 关键词：coupled oscillators ; cyclin/CDK machinery ; single cell ; microfluidics ; FRET sensor ; NAD(P)H ; metabolic oscillations ; cell cycle ; yeast metabolic cycle ; Saccharomyces cerevisiae
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：285-295
• 全文大小：3804 K
• 卷排序：65

文摘

Metabolic cycles are an intrinsic, growth-condition-independent behavior of single cells The metabolic oscillations are not the result of the cell cycle and thus are autonomous The metabolic oscillator and the cyclin/CDK machinery form a system of coupled oscillators Both the early and late cell cycle operate in coordination with the metabolic oscillator