Anaplastic Lymphoma Kinase-Negative Anaplastic Large Cell Lymphoma Manifesting as a Scalp Hematoma After an Acute Head Injury—a Case Report and Literature Review

详细信息    查看全文

• 作者：Chi-Yung Yeung¹ ; Kun-Ting Hong² ; Chien-Ping Chiang³ ; Yuan-Hao Chen² ; Hsin-I Ma² ; Tung-Hang Tsai² ; ^{tunghantsai269@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Anaplastic large cell lymphoma (ALCL) ; Anaplastic lymphoma kinase (ALK) ; Head injury ; Scalp hematoma
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：88
• 期：Complete
• 页码：688.e13-688.e16
• 全文大小：2210 K

文摘

Anaplastic large cell lymphoma (ALCL) is a malignant non-Hodgkin lymphoma, typically associated with anaplastic lymphoma kinase (ALK) expression. In some cases, lack of ALK translocation correlated with a more unfavorable prognosis.

Case Description

We describe a case of ALK⁻ ALCL that manifested as a progressive, enlarged, swollen mass on the scalp after an acute head injury in an 84-year-old man. Neither palpable lymph nodes nor any B symptoms were noted on admission. Brain computed tomography showed a hematoma in the right posterior occipital region of the scalp as the only remarkable finding. Débridement and biopsy were performed. Histologic and immunohistochemical analysis of the specimen revealed an ALK⁻ ALCL of the scalp. The lymphoma was resistant to bendamustine-containing chemotherapies, ultimately leading to the patient's death within 2 months.

Conclusions

This case report highlights the importance of recognizing the possibility of an ALCL manifesting as a focal inflammatory swelling mass on the scalp.