Identification of putative drug targets in Vancomycin-resistant Staphylococcus aureus (VRSA) using computer aided protein data analysis
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- 作者：Md. Anayet Hasana ; anayet_johny@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Md. Arif Khanb ; Tahmina Sharminb ; Md. Habibul Hasan Mazumdera ; Afrin Sultana Chowdhurya
- 关键词：MRSA ; Methicillin-resistant Staphylococcus aureus ; VISA ; Vancomycin-intermediate-resistant Staphylococcus aureus ; VRSA ; Vancomycin-resistant Staphylococcus aureus ; CD-HIT ; Cluster Database at High Identity with Tolerance ; BLAST ; Basic Local Alignment Search Tool ; E-value ; expectation value ; MSP ; maximal segment pair ; DEG ; database of essential gene ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; KAAS ; KEGG Automatic Annotation Server ; SVM ; Support Vector Machine ; DB ; Drug Bank ; FDA ; Food and Dru
- 刊名：Gene
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：575
- 期：1
- 页码：132-143
- 全文大小：1464 K
文摘
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We identified potential drug target for VRSA strains.
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We selected non-human homologue essential proteins involved in metabolic pathways.
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19 proteins in unique pathways were found.
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26 human nonhomologous membrane-bound proteins were identified.
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pbpA penicillin-binding protein 1 and hypothetical protein MQW_01796 as the best drug target
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