Crystal Structure of the Vanadate-Inhibited Ca2+-ATPase
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- 作者：Johannes D. Clausen1 ; 2 ; 3 ; 5 ; 6 ; Maike Bublitz1 ; 2 ; 5 ; 7 ; Bertrand Arnou1 ; 2 ; Claus Olesen1 ; 2 ; 3 ; Jens Peter Andersen3 ; Jesper Vuust Mø ; ller2 ; 3 ; Poul Nissen1 ; 2 ; 4 ; pn@mbg.au.dk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：24
- 期：4
- 页码：617-623
- 全文大小：2693 K
文摘
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Orthovanadate marks a trigonal bipyramidal intermediate of SERCA dephosphorylation
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Decavanadate inhibits SERCA by competing with nucleotide for binding
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A chloride-binding site is identified near the SERCA phosphorylation site
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Trinitrophenyl derivatives map different nucleotide-binding poses in SERCA