ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
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- 作者：Sunghee Park1 ; Ching-Yi Chang1 ; Rachid Safi1 ; Xiaojing Liu1 ; Robert Baldi1 ; Jeff S. Jasper1 ; Grace R. Anderson1 ; Tingyu Liu1 ; Jeffrey C. Rathmell1 ; Mark W. Dewhirst2 ; Kris C. Wood1 ; Jason W. Locasale1 ; Donald P. McDonnell1 ; donald.mcdonnell@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 April 2016
- 年：2016
- 卷：15
- 期：2
- 页码：323-335
- 全文大小：3243 K
文摘
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Oxidation of lactate allows breast cancer cells to withstand fluctuations in glucose availability
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ERRα antagonists disrupt mitochondrial function, inhibit lactate utilization, and compromise cancer cell viability
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Breast cancer cells utilizing lactate are insensitive to PI3K/mTOR inhibitors
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ERRα antagonists increase the activity of clinically relevant PI3K/mTOR inhibitors