The adrenal specific toxicant mitotane directly interacts with lipid membranes and alters membrane properties depending on lipid composition
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- 作者：Holger A. Scheidta ; Ivan Haralampievb ; Stephan Theisgena ; Andreas Schirbelc ; Silviu Sbierad ; Daniel Hustera ; Matthias Kroissd ; Peter Mü ; llerb ; peter.mueller.3@rz.hu-berlin.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitotane ; Lipid vesicles ; Membrane structure ; Spin-labeled lipid ; Fluorescent lipid ; Order parameter ; Lipid&ndash ; drug interaction
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：428
- 期：Complete
- 页码：68-81
- 全文大小：2640 K
文摘
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The drugs mitotane and o,p′-DDA bind to lipid membranes by intercalation into the lipid–water interface of the bilayer.
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Mitotane mediates a disturbance of membrane bilayer structure.
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The impact of mitotane on bilayer structure depends on the membrane lipid composition.
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o,p′-DDA shows no impact on membranes.