Dextran sulphate sodium colitis in C57BL/6J mice is alleviated by Lactococcus lactis and worsened by the neutralization of Tumor necrosis Factor α

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• 作者：Ale&scaron ; Berlec^a ; ¹ ; ^{ales.berlec@ijs.si} ; Martina Per&scaron ; e^b ; ¹ ; Matjaž Ravnikar^c ; Mojca Lunder^c ; Andreja Erman^d ; Anton Cerar^b ; Borut &Scaron ; trukelj^a ; ^c
• 关键词：ΤΝFα ; Tumor Necrosis Factor α ; DSS ; dextran sulphate sodium ; IBD ; inflammatory bowel disease ; CD ; Crohn's disease ; UC ; ulcerative colitis ; LAB ; lactic acid bacteria ; GM-17 ; M-17 medium with 0.5% glucose
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：219-226
• 全文大小：1596 K
• 卷排序：43

文摘

TNFα-binding and control L. lactis were compared with anti-TNFα antibody in colitis. L. lactis alleviated the DSS colitis, particularly in preventive administration. Detrimental effect of TNFα neutralization was observed. TNFα neutralization without DSS induction highly increased tissue TNFα.