Pain Flare Is a Common Adverse Event in Steroid-Na?ve Patients After Spine Stereotactic Body Radiation Therapy: A Prospective Clinical Trial

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• 作者：Andrew Chiang ; MD^&lowast ; ; ^&dagger ; ; Liang Zeng ; MD(C)^&lowast ; ; Liying Zhang ; PhD^&lowast ; ; Fiona Lochray ; MRTT^&lowast ; ; Renee Korol ; PhD^&lowast ; ; Andrew Loblaw ; MD^&lowast ; ; Edward Chow ; MBBS ; PhD^&lowast ; ; Arjun Sahgal ; MD^&lowast ; ; ^&dagger ; ; ^{arjun.sahgal@sunnybrook.ca}
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2013
• 出版时间：15 July, 2013
• 年：2013
• 卷：86
• 期：4
• 页码：638-642
• 全文大小：406 K

文摘

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Purpose

To determine the incidence of pain flare after spine stereotactic body radiation therapy (SBRT) in steroid-na?ve patients and identify predictive factors.

Methods and Materials

Forty-one patients were treated with spine SBRT between February 2010 and April 2012. All patients had their pain assessed at baseline, during, and for 10 days after SBRT using the Brief Pain Inventory. All pain medications were recorded daily and narcotics converted to an oral morphine equivalent dose. Pain flare was defined as a 2-point increase in worst pain score as compared with baseline with no decrease in analgesic intake, a 25 % increase in analgesic intake as compared with baseline with no decrease in worst pain score, or if corticosteroids were initiated at any point during or after SBRT because of pain.

Results

The median age and Karnofsky performance status were 57.5 years (range, 27-80 years) and 80 (range, 50-100), respectively. Eighteen patients were treated with 20-24 Gy in a single fraction, whereas 23 patients were treated with 24-35 Gy in 2-5 fractions. Pain flare was observed in 68.3 % of patients (28 of 41), most commonly on day 1 after SBRT (29 % , 8 of 28). Multivariate analysis identified a higher Karnofsky performance status (P=.02) and cervical (P=.049) or lumbar (P=.02) locations as significant predictors of pain flare. In those rescued with dexamethasone, a significant decrease in pain scores over time was subsequently observed (P<.0001).

Conclusions

Pain flare is a common adverse event after spine SBRT and occurs most commonly the day after treatment completion. Patients should be appropriately consented for this adverse event.