Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress

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• 作者：Tatiana A. Chernova¹ ; ⁷ ; ^{tcherno@emory.edu} ; Denis A. Kiktev² ; ⁴ ; ⁵ ; Andrey V. Romanyuk² ; John R. Shanks¹ ; Oskar Laur³ ; Moiez Ali¹ ; ⁶ ; Abheek Ghosh¹ ; Dami Kim¹ ; Zhen Yang¹ ; Maggie Mang¹ ; Yury O. Chernoff² ; ⁴ ; ^{yury.chernoff@biology.gatech.edu} ; Keith D. Wilkinson¹ ; ^{genekdw@emory.edu}
• 关键词：amyloids ; prions ; actin ; ubiquitination ; Sup35 ; environmental stress ; heat shock ; chaperone
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：751-761
• 全文大小：3269 K
• 卷排序：18

文摘

Yeast protein Lsb2 forms a metastable prion inducing formation of other prions Thermal stress triggers formation of the metastable prion state of Lsb2 Lsb2 has acquired prion activity in evolution due to a single amino acid change This change coincides with yeast adaptation to higher growth temperatures