One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water

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• 作者：Jü ; rgen Hö ; lzer ; Thomas Gö ; en ; Knut Rauchfuss ; Martin Kraft ; Jü ; rgen Angerer ; Peter Kleeschulte ; Michael Wilhelm
• 关键词：Perfluorinated compounds ; PFC ; PFOA ; PFOS ; Human biomonitoring ; Follow-up ; Children ; Adults ; PFC study Sauerland ; Elimination rate
• 刊名：International Journal of Hygiene and Environmental Health
• 出版年：2009
• 出版时间：September 2009
• 年：2009
• 卷：212
• 期：5
• 页码：499-504
• 全文大小：246 K

文摘

In Arnsberg, Sauerland area Germany, 40 000 residents were exposed to PFOA-contaminated drinking water (500-640 ng PFOA/l; May 2006). In July 2006, the PFOA-concentrations in drinking water were lowered significantly by activated charcoal filtering in the waterworks, mostly below the limit of detection (10 ng/l). A first human biomonitoring study performed in autumn 2006 revealed that PFOA-concentrations in blood plasma of residents living in Arnsberg were 4.5–8.3 times higher than in the reference groups. One year after the first survey, all participants (2006: 164 mothers, 90 children, 101 men) were invited to take part in a follow-up study. It was the aim of the study to determine the decline of the PFOA-concentrations in blood plasma. 288 persons (81 % ) were included in the statistical analysis. The (geometric) mean PFOA-concentrations in blood plasma of Arnsberg's residents decreased from 22.1 to 17.4 μg/l in children, from 23.4 to 18.8 μg/l in mothers and from 25.3 to 23.4 μg/l in men within one year. The average (geometric mean) changes in each individual's PFOA-concentrations were approximately 10 (men), 17 (mothers) and 20 (children) percent/year. The observed decline in PFOA-concentrations indicates a slow elimination in humans. This finding in groups of the general population is in agreement with data on long elimination half-lives observed in occupationally exposed workers.